BDBM50435351 CHEMBL2391550

SMILES O=C(CCc1cccnc1)Nc1ccc(cc1)S(=O)(=O)c1ccccc1

InChI Key InChIKey=ZBBMPYVJMJCAIO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50435351   

TargetNicotinamide phosphoribosyltransferase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50435351(CHEMBL2391550)
Affinity DataIC50: 21nMAssay Description:Competitive inhibition of Nampt (unknown origin) after 15 mins in presence of 1 uM NAMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50435351(CHEMBL2391550)
Affinity DataIC50: 28nMAssay Description:Inhibition of Nampt (unknown origin) using NAM/PRPP as substrate preincubated for 15 mins measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50435351(CHEMBL2391550)
Affinity DataIC50: 64nMAssay Description:Competitive inhibition of Nampt (unknown origin) after 15 mins in presence of 5 uM NAMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50435351(CHEMBL2391550)
Affinity DataIC50: 195nMAssay Description:Competitive inhibition of Nampt (unknown origin) after 15 mins in presence of 25 uM NAMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50435351(CHEMBL2391550)
Affinity DataIC50: 1.25E+3nMAssay Description:Competitive inhibition of Nampt (unknown origin) after 15 mins in presence of 125 uM NAMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50435351(CHEMBL2391550)
Affinity DataIC50: 3.00E+3nMAssay Description:Competitive inhibition of Nampt (unknown origin) after 15 mins in presence of 250 uM NAMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed