BDBM50439523 CHEMBL2418343
SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(N2CCOC[C@H]2C)c2n(C)cnc2n1
InChI Key InChIKey=VNORXAXGKIUEIT-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50439523
Affinity DataKi: 69nMAssay Description:Inhibition of human recombinant mTOR (1360-2549) expressed in insect cells assessed as phosphorylation of recombinant (GFP)-4-EBP1 after 30 mins by L...More data for this Ligand-Target Pair
Affinity DataIC50: 650nMAssay Description:Inhibition of mTOR in PTEN deficient human PC3 cells assessed as inhibition of Akt phosphorylation at Ser473More data for this Ligand-Target Pair
Affinity DataIC50: 730nMAssay Description:Inhibition of mTOR in PTEN deficient human PC3 cells assessed as inhibition of p70S6K phosphorylationMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Displacement of TAMRA-PIP3 from PI3Kdelta GRP-1 pleckstrin homology domain (unknown origin) assessed as formation of 3,4,5-inositoltriphosphate after...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataIC50: 5.80E+3nMAssay Description:Displacement of TAMRA-PIP3 from PI3Kalpha GRP-1 pleckstrin homology domain (unknown origin) assessed as formation of 3,4,5-inositoltriphosphate after...More data for this Ligand-Target Pair