BDBM504397 (S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[1,2-b]pyridazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethanamine ::US11040979, Compound 1

SMILES Cn1cc(cn1)-c1cc2c(ccnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1

InChI Key InChIKey=NQJMXKIPWGAUKR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 504397   

TargetPlatelet-derived growth factor receptor alpha [D842V](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM504397((S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyr...)
Affinity DataIC50: 1nMAssay Description:KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [V560G](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM504397((S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyr...)
Affinity DataIC50: 5.5nMAssay Description:KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [V559D,T670I](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM504397((S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyr...)
Affinity DataIC50: 5.5nMAssay Description:KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [V559D,V654A](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM504397((S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyr...)
Affinity DataIC50: 5.5nMAssay Description:KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM504397((S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyr...)
Affinity DataIC50: 100nMAssay Description:KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
US Patent