BDBM504400 (S)-4-(4-(5-(1-amino-1-(4-fluorophenyl)ethyl)pyrimidin-2-yl)piperazin-1-yl)-6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[1,2-b]pyridazine-3-carbonitrile ::US11040979, Compound 4

SMILES Cn1cc(cn1)-c1cc2c(N3CCN(CC3)c3ncc(cn3)[C@@](C)(N)c3ccc(F)cc3)c(cnn2c1)C#N

InChI Key InChIKey=WJPCHYUNFBBRCP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 504400   

TargetMast/stem cell growth factor receptor Kit(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM504400((S)-4-(4-(5-(1-amino-1-(4-fluorophenyl)ethyl)pyrim...)
Affinity DataIC50: 100nMAssay Description:KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
Go to US Patent

TargetMast/stem cell growth factor receptor Kit [V560G](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM504400((S)-4-(4-(5-(1-amino-1-(4-fluorophenyl)ethyl)pyrim...)
Affinity DataIC50: 5.5nMAssay Description:KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
Go to US Patent

TargetMast/stem cell growth factor receptor Kit [V559D,T670I](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM504400((S)-4-(4-(5-(1-amino-1-(4-fluorophenyl)ethyl)pyrim...)
Affinity DataIC50: 5.5nMAssay Description:KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
Go to US Patent

TargetMast/stem cell growth factor receptor Kit [V559D,V654A](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM504400((S)-4-(4-(5-(1-amino-1-(4-fluorophenyl)ethyl)pyrim...)
Affinity DataIC50: 55nMAssay Description:KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor alpha [D842V](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM504400((S)-4-(4-(5-(1-amino-1-(4-fluorophenyl)ethyl)pyrim...)
Affinity DataIC50: 1nMAssay Description:KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
Go to US Patent