BDBM50440217 CHEMBL2426645

SMILES CC(C)(C(c1ccccc1)c1ccc2n(ncc2c1)-c1ccc(Cl)cc1)C(=O)Nc1nncs1

InChI Key InChIKey=NDQPXLMAPGHANG-UHFFFAOYSA-N

Data  1 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50440217   

TargetGlucocorticoid receptor(Human)
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440217(CHEMBL2426645)
Affinity DataEC50:  10nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of IL-1beta-induced NF-kappaB dependent E-selectin activation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440217(CHEMBL2426645)
Affinity DataKi:  18nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440217(CHEMBL2426645)
Affinity DataEC50:  23nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of PMA-induced AP-1 activation by luciferase reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440217(CHEMBL2426645)
Affinity DataEC50:  256nMAssay Description:Transactivation of glucocorticoid receptor ligand binding domain (unknown origin) transfected in human HeLa cells assessed as activation of NP-1 by G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed