BDBM50440246 CHEMBL2426658

SMILES CC(C)([C@@H](c1ccccc1)c1ccc2[nH]ncc2c1)C(=O)Nc1nncs1

InChI Key InChIKey=QVPPKBMLWHQBMA-UHFFFAOYSA-N

Data  1 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50440246   

TargetGlucocorticoid receptor(Human)
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440246(CHEMBL2426658)
Affinity DataKi:  2.70nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440246(CHEMBL2426658)
Affinity DataEC50:  15nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of IL-1beta-induced NF-kappaB dependent E-selectin activation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440246(CHEMBL2426658)
Affinity DataEC50:  24nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of PMA-induced AP-1 activation by luciferase reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440246(CHEMBL2426658)
Affinity DataEC50:  208nMAssay Description:Transactivation of glucocorticoid receptor ligand binding domain (unknown origin) transfected in human HeLa cells assessed as activation of NP-1 by G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed