BDBM50440796 CHEMBL2431398

SMILES Cc1nc2c(cc(nc2n1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1)C(O)=O

InChI Key InChIKey=DQFJQMDNPRZOAO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50440796   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50440796(CHEMBL2431398)
Affinity DataIC50: 5nMAssay Description:Inhibition of PI3Kbeta (unknown origin) assessed as PIP2 conversion to PIP3 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50440796(CHEMBL2431398)
Affinity DataIC50: 436nMAssay Description:Inhibition of PI3Kbeta-mediated AKT phosphorylation at Ser473 in PTEN-deficient human MDA-MB-468 cells after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed