BDBM50440906 CHEMBL2431819
SMILES C[C@H](c1nnc2ccc(nn12)-c1cnn(C)c1)c1ccc2ncccc2c1
InChI Key InChIKey=VQYHPUHKYSSEOB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50440906
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human c-Met H1094R mutant expressed in mouse 3T3 cells assessed as reduction in cellular c-Met phosphorylation incubated for 1 hr follo...More data for this Ligand-Target Pair
Affinity DataIC50: 5.60nMAssay Description:Inhibition of wild type endogenous c-Met in human A549 cells assessed as reduction in cellular c-Met phosphorylation incubated for 1 hr followed by 2...More data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:Inhibition of wild type human c-Met expressed in human T47D cells assessed as reduction in cellular c-Met phosphorylation incubated for 1 hr followed...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of His6-tagged human c-Met H1094R mutant expressed in Sf9 cells pre-incubated with enzyme for 30 mins prior to addition of ATP using (Glu4...More data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of wild type human c-Met expressed in mouse 3T3 cells assessed as reduction in cellular c-Met phosphorylation incubated for 1 hr followed ...More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Inhibition of His6-tagged wild type human c-Met expressed in Sf9 cells using (Glu4Tyr) or Met2 peptide substrate by coupled enzymatic assayMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of un -tagged wild type human c-Met expressed in Sf9 cells pre-incubated with enzyme for 30 mins prior to addition of ATP using (Glu4Tyr) ...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of human c-Met M1250T mutant expressed in mouse 3T3 cells assessed as reduction in cellular c-Met phosphorylation incubated for 1 hr follo...More data for this Ligand-Target Pair
Affinity DataKi: 49nMAssay Description:Inhibition of His6-tagged human c-Met Y1235D mutant expressed in Sf9 cells pre-incubated with enzyme for 30 mins prior to addition of ATP using (Glu4...More data for this Ligand-Target Pair
Affinity DataIC50: 153nMAssay Description:Inhibition of human c-Met Y1235D mutant expressed in human T47D cells assessed as reduction in cellular c-Met phosphorylation incubated for 1 hr foll...More data for this Ligand-Target Pair
Affinity DataKi: 692nMAssay Description:Inhibition of His6-tagged human c-Met L1195V mutant expressed in Sf9 cells pre-incubated with enzyme for 30 mins prior to addition of ATP using (Glu4...More data for this Ligand-Target Pair
Affinity DataKi: >2.50E+3nMAssay Description:Inhibition of His6-tagged human c-Met D1228H mutant expressed in Sf9 cells pre-incubated with enzyme for 30 mins prior to addition of ATP using (Glu4...More data for this Ligand-Target Pair
Affinity DataKi: 8.90E+3nMAssay Description:Inhibition of His6-tagged human c-Met Y1230H mutant expressed in Sf9 cells pre-incubated with enzyme for 30 mins prior to addition of ATP using (Glu4...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of His6-tagged human c-Met Y1230C mutant expressed in Sf9 cells pre-incubated with enzyme for 30 mins prior to addition of ATP using (Glu4...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human c-Met Y1230C mutant expressed in mouse 3T3 cells assessed as reduction in cellular c-Met phosphorylation incubated for 1 hr follo...More data for this Ligand-Target Pair