BDBM50442609 CHEMBL2441417

SMILES Cc1c2COC(=O)c2ccc1CCN1CCN(CC1)C(=O)Cc1ccc(cc1)-n1cnnn1

InChI Key InChIKey=INGZRGKJUHWGLX-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50442609   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442609(CHEMBL2441417)
Affinity DataIC50: 72nMAssay Description:Inhibition of human ROMK expressed in CHO cells by whole-cell voltage clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442609(CHEMBL2441417)
Affinity DataIC50: 72nMAssay Description:Inhibition of human ROMK channel by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442609(CHEMBL2441417)
Affinity DataIC50: 190nMAssay Description:Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by [86Rb+] flux functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442609(CHEMBL2441417)
Affinity DataIC50: 190nMAssay Description:Inhibition of ROMK (unknown origin) after 30 mins by 86Rb+ efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442609(CHEMBL2441417)
Affinity DataIC50: 190nMAssay Description:Inhibition of ROMK (unknown origin) after 30 mins by 86Rb+ efflux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442609(CHEMBL2441417)
Affinity DataIC50: 190nMAssay Description:Inhibition of human ROMK channel-mediated 86Rb+ flux expressed in CHO cells after 35 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442609(CHEMBL2441417)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human ERG by electrophysiology analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442609(CHEMBL2441417)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [35S]-MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442609(CHEMBL2441417)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [35S]MK-499 from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442609(CHEMBL2441417)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [35S]MK-499 from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed