BDBM50443710 CHEMBL3093863::US9238658, 37

SMILES Fc1ccc2CCN(C3CCN(CC3)C(=O)Nc3cc4C(=O)NCCn4n3)c2c1

InChI Key InChIKey=RJNFVDPBBUNVSC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50443710   

TargetAcyl-CoA desaturase 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50443710(CHEMBL3093863 | US9238658, 37)
Affinity DataIC50: 14nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 uL using 10 ug of RLM (prepared as described above) in a 96-well polypropylene plate (enzyme reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetAcyl-CoA desaturase 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50443710(CHEMBL3093863 | US9238658, 37)
Affinity DataIC50: 18nMAssay Description:Inhibition of SCD1 in Sprague-Dawley rat liver microsomes using Stearoyl-[9,10-3H]-CoA as substrate assessed as [3H2O] generationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50443710(CHEMBL3093863 | US9238658, 37)
Affinity DataIC50: 22nMT: 2°CAssay Description:The SCD1 enzymatic assay was done in a volume of 50 uL using 10 ug of RLM (prepared as described above) in a 96-well polypropylene plate (enzyme reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent