BDBM50448773 CHEMBL3128057

SMILES CC(C)(O)C#Cc1ccc2cnn(-c3ccnc(N)n3)c2c1

InChI Key InChIKey=MVGFFUCPMFAGBV-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50448773   

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448773BDBM50448773(CHEMBL3128057)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of PIKfyve (unknown origin) using PI(3)P:PS as substrate incubated for 60 mins in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448773BDBM50448773(CHEMBL3128057)
Affinity DataIC50: 18nMAssay Description:Inhibition of PIKfyve (unknown origin) expressed in HEK293 cells using NanoBRET NanoGlo substrate in presence of K8 tracer by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448773BDBM50448773(CHEMBL3128057)
Affinity DataKi:  120nMAssay Description:Binding affinity to N-terminal GST-tagged recombinant human PAK4 kinase domain expressed in Escherichia coli using KKRNRRLSVA as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448773BDBM50448773(CHEMBL3128057)
Affinity DataKi: >4.50E+3nMAssay Description:Binding affinity to N-terminal GST-His-tagged recombinant human PAK1 kinase domain expressed in Escherichia coli BL21 using KKRNRRLSVA as sustrate pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed