BDBM50448935 CHEMBL3125528::US9296736, 304::US9593129, Example 304

SMILES CC[C@@H](CS(=O)(=O)CC1CC1)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1

InChI Key InChIKey=PHSXCIHKZKDKHQ-ONRXEWETSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50448935   

LigandPNGBDBM50448935(CHEMBL3125528 | US9296736, 304 | US9593129, Exampl...)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50448935(CHEMBL3125528 | US9296736, 304 | US9593129, Exampl...)
Affinity DataIC50:  0.300nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50448935(CHEMBL3125528 | US9296736, 304 | US9593129, Exampl...)
Affinity DataIC50:  0.200nMAssay Description:Binding affinity to human GST-thrombin-tagged MDM2 assessed as inhibition of interaction with human p53 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50448935(CHEMBL3125528 | US9296736, 304 | US9593129, Exampl...)
Affinity DataIC50:  1.80nMAssay Description:Binding affinity to human GST-thrombin-tagged MDM2 assessed as inhibition of interaction with human p53 after 1 hr by HTRF assay in presence of 15% h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed