BDBM50449429 2-(3-Nitrophenyl)-4H-3,1-benzoxazin-4-one (18)::CHEMBL422484

SMILES [O-][N+](=O)c1cccc(c1)-c1nc2ccccc2c(=O)o1

InChI Key InChIKey=WKYQIWUAPDQQRV-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50449429   

TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50449429(CHEMBL422484 | 2-(3-Nitrophenyl)-4H-3,1-benzoxazin...)
Affinity DataKi:  3.98E+3nMAssay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetChymotrypsinogen A(Bovine)
University of Karachi

LigandPNGBDBM50449429(CHEMBL422484 | 2-(3-Nitrophenyl)-4H-3,1-benzoxazin...)
Affinity DataIC50: 3.41E+5nMpH: 7.6Assay Description:The α-chymotrypsin inhibition activity was evaluated in 50 mM Tris-HCl buffer pH 7.6 with 10 mM CaCl2. α-Chymotrypsin (bovine pancreas) at ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2017
Entry Details Article
PubMed
TargetChymotrypsinogen A(Bovine)
University of Karachi

LigandPNGBDBM50449429(CHEMBL422484 | 2-(3-Nitrophenyl)-4H-3,1-benzoxazin...)
Affinity DataKi:  3.41E+5nMAssay Description:The change in optical density per minute (OD/min) was obtained by incorporating various concentrations of compounds over a range of substrate (SPpNA)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2017
Entry Details Article
PubMed