BDBM50450477 CHEMBL4164767::US10597366, Compound 16

SMILES O[C@H]1CCc2c1c(ccc2Oc1cc(F)cc(Cl)c1)S(=O)(=O)C(F)F

InChI Key InChIKey=FJZLLSMTDQFRCS-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50450477   

TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50450477(CHEMBL4164767 | US10597366, Compound 16)
Affinity DataIC50: 460nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50450477(CHEMBL4164767 | US10597366, Compound 16)
Affinity DataIC50: 980nMAssay Description:HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
US Patent

TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50450477(CHEMBL4164767 | US10597366, Compound 16)
Affinity DataEC50:  2.90E+3nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed