BDBM50450854 CHEMBL4208876

SMILES Cc1n[nH]cc1-c1cc2N[C@]3(CC[C@@](O)(CC3)C3CCCCC3)NC(=O)c2s1

InChI Key InChIKey=JEMZAKZZKHRMHZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50450854   

TargetRho-associated protein kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50450854(CHEMBL4208876)
Affinity DataIC50: 350nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ROCK1 (1 to 477 residues) expressed in baculovirus expression system using biotin-STK substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50450854(CHEMBL4208876)
Affinity DataIC50: 380nMAssay Description:Inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged DBF4 (1 to 674 residues) expressed in baculovirus expression sys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50450854(CHEMBL4208876)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human Cdk2 (1 to 298 residues)/human N-terminal GST-tagged cyclinE (1 to 410 residues) expressed in baculovirus expression ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed