BDBM50450867 CHEMBL4206501

SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1ccnc(n1)-c1cn(C)c2ccccc12

InChI Key InChIKey=BVNDWJSTWPXVCD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50450867   

TargetEpidermal growth factor receptor(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50450867(CHEMBL4206501)
Affinity DataIC50: 13nMAssay Description:Inhibition of EGFR T790M/exon 19 deletion mutant phosphorylation in human PC9-DRH cells preincubated for 2 hrs followed by EGF stimulation for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50450867(CHEMBL4206501)
Affinity DataIC50: 15nMAssay Description:Inhibition of EGFR T790M/L858R double mutant phosphorylation in human H1975 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50450867(CHEMBL4206501)
Affinity DataIC50: 36nMAssay Description:Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50450867(CHEMBL4206501)
Affinity DataIC50: 56nMAssay Description:Inhibition of EGFR exon 19 deletion mutant phosphorylation in human PC9 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50450867(CHEMBL4206501)
Affinity DataIC50: 152nMAssay Description:Inhibition of EGF-stimulated wild-type EGFR phosphorylation in human A549 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by san...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed