BDBM50452364 CHEMBL2237704

SMILES COc1ccc(\C=C\C(=O)c2ccncc2)cc1

InChI Key InChIKey=LMHRAMCQWYNSSF-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50452364   

TargetCytochrome P450 2C9(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50452364(CHEMBL2237704)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human CYP2C9 expressed in yeast microsomal membranes using 3-cyano-7-ethoxycoumarin as substrate measured after 10 mins by fluorescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrophozoite cysteine proteinase(malaria parasite P. falciparum)TBA
LigandPNGBDBM50452364(CHEMBL2237704)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of Plasmodium falciparum W2 cysteine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCytochrome P450 1A2(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50452364(CHEMBL2237704)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of recombinant human CYP1A2 expressed in HEK293 cells using 3-cyano-7-ethoxycoumarin as substrate pretreated for 30 mins followed by subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50452364(CHEMBL2237704)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CYP2D6 expressed in HEK293 cells using 7-ethoxy-methyloxy-3-cyanocoumarin as substrate pretreated for 30 mins followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50452364(CHEMBL2237704)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human CYP2C19 expressed in yeast microsomal membranes using 3-cyano-7-ethoxycoumarin as substrate measured after 10 mins by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50452364(CHEMBL2237704)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human CYP3A4 expressed in yeast microsomal membranes using dibenzylfluorescein as substrate measured after 10 mins by fluorescence assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50452364(CHEMBL2237704)
Affinity DataIC50:  6.61E+3nMAssay Description:Inhibition of recombinant human CYP1A1 expressed in HEK293 cells using 7-ethoxyresorufin as substrate pretreated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50452364(CHEMBL2237704)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of human CYP1A2 expressed in yeast microsomal membranes using 3-cyano-7-ethoxycoumarin as substrate measured after 10 mins by fluorescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50452364(CHEMBL2237704)
Affinity DataIC50:  8.52E+3nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in HEK293 cells using 7-ethoxyresorufin as substrate pretreated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50452364(CHEMBL2237704)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of human CYP2D6 expressed in yeast microsomal membranes using 7-ethoxy-methyloxy-3-cyanocoumarin as substrate measured after 10 mins by fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50452364(CHEMBL2237704)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in HEK293 cells using dibenzylfluorescein as substrate pretreated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50452364(CHEMBL2237704)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CYP2C9 expressed in HEK293 cells using 3-cyano-7-ethoxycoumarin as substrate pretreated for 30 mins followed by subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50452364(CHEMBL2237704)
Affinity DataIC50:  6.31E+3nMAssay Description:Inhibition of human CYP1A1 expressed in yeast microsomal membranes using 7-ethoxyresorufin as substrate measured after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50452364(CHEMBL2237704)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of human CYP1B1 expressed in yeast microsomal membranes using 7-ethoxyresorufin as substrate measured after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrophozoite cysteine proteinase(malaria parasite P. falciparum)TBA
LigandPNGBDBM50452364(CHEMBL2237704)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of Plasmodium falciparum W2 cysteine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCytochrome P450 2C19(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50452364(CHEMBL2237704)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CYP2C19 expressed in HEK293 cells using 3-cyano-7-ethoxycoumarin as substrate pretreated for 30 mins followed by subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed