BDBM50453781 CHEMBL4218866

SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ncnc(-c3c[nH]c4cnccc34)c21

InChI Key InChIKey=HCUCIJYVGFNKLN-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50453781   

TargetBromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50453781(CHEMBL4218866)
Affinity DataKi:  7nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human N-terminal His6-tagged BRD4 bromodomain 2 (333 to 460 residues) expressed in Rosetta2 D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50453781(CHEMBL4218866)
Affinity DataKi:  7.10nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human N-terminal His6-tagged BRD4 bromodomain 1 (44 to 168 residues) expressed in Rosetta2 DE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50453781(CHEMBL4218866)
Affinity DataIC50: 12nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human N-terminal His6-tagged BRD4 bromodomain 2 (333 to 460 residues) expressed in Rosetta2 D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50453781(CHEMBL4218866)
Affinity DataIC50: 23nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human N-terminal His6-tagged BRD4 bromodomain 1 (44 to 168 residues) expressed in Rosetta2 DE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed