BDBM50453822 CHEMBL3969370

SMILES CN1c2ccc(C)cc2C(=O)N(C)c2cnc(Nc3ccc(NC(=O)c4ccc(NC(=O)C=C)cc4)cc3)nc12

InChI Key InChIKey=CPKWRHVMDOSXKE-UHFFFAOYSA-N

Data  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50453822   

TargetAurora kinase A(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453822(CHEMBL3969370)
Affinity DataEC50:  5.80nMAssay Description:Inhibition of Aurora A auto-phosphorylation in human HCT116 cells after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453822(CHEMBL3969370)
Affinity DataEC50:  7.10nMAssay Description:Inhibition of Aurora B in human HCT116 cells assessed as reduction in histone H3 phosphorylation at S10 residues after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453822(CHEMBL3969370)
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant full length His-tagged human Aurora B expressed in baculovirus expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453822(CHEMBL3969370)
Affinity DataIC50: 44nMAssay Description:Inhibition of recombinant full length His-tagged human Aurora A expressed in baculovirus expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453822(CHEMBL3969370)
Affinity DataIC50: 44nMAssay Description:Inhibition of GST-tagged human PLK4 (1 to 836 residues) by Lanthascreen binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAurora kinase C(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453822(CHEMBL3969370)
Affinity DataIC50: 63nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora C expressed in baculovirus expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453822(CHEMBL3969370)
Affinity DataIC50: 754nMAssay Description:Inhibition of recombinant GST-tagged human LRRK2 (970 to 2527 residues) catalytic domain expressed in baculovirus expression system by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50453822(CHEMBL3969370)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of BRD4 (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed