BDBM50453958 CHEMBL4209359::US11247989, Example 77

SMILES COc1cncc2c(cccc12)-c1nn(C2CCOCC2)c2CCN(Cc12)C(C)=O

InChI Key InChIKey=GAVVBDXGDAIREU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50453958   

TargetCREB-binding protein(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50453958(CHEMBL4209359 | US11247989, Example 77)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant His-tagged CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50453958(CHEMBL4209359 | US11247989, Example 77)
Affinity DataIC50: 23.3nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50453958(CHEMBL4209359 | US11247989, Example 77)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of BRD4 bromodomain 1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed