BDBM50453980 CHEMBL4217552::US11247989, Example 76

SMILES COc1ccc(-c2nn(C3CCOCC3)c3CCN(Cc23)C(C)=O)c2cnccc12

InChI Key InChIKey=XGLAIMCDIMBGPK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50453980   

TargetCREB-binding protein(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50453980(CHEMBL4217552 | US11247989, Example 76)
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant His-tagged CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50453980(CHEMBL4217552 | US11247989, Example 76)
Affinity DataIC50: 27.2nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50453980(CHEMBL4217552 | US11247989, Example 76)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of BRD4 bromodomain 1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed