BDBM50457222 CHEMBL4207101

SMILES Fc1cc(F)cc(CNCC(=O)Nc2ccc3nc4CCCn4c(=O)c3c2)c1

InChI Key InChIKey=NLUCFDWSIZAJOW-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50457222   

TargetCholinesterase(Human)
Xinyang Normal University

Curated by ChEMBL
LigandPNGBDBM50457222(CHEMBL4207101)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human BChE pre-incubated for 6 mins before ATCI substrate addition and measured after 12 mins by DTNB reagent dependent UV-Vis spectrop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Xinyang Normal University

Curated by ChEMBL
LigandPNGBDBM50457222(CHEMBL4207101)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of human AChE pre-incubated for 6 mins before ATCI substrate addition and measured after 12 mins by DTNB reagent dependent UV-Vis spectrop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Xinyang Normal University

Curated by ChEMBL
LigandPNGBDBM50457222(CHEMBL4207101)
Affinity DataKi:  9.90nMAssay Description:Inhibition of human AChE assessed as inhibitor dissociation constant for enzyme-inhibitor complex pre-incubated for 6 mins before ATCI substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Xinyang Normal University

Curated by ChEMBL
LigandPNGBDBM50457222(CHEMBL4207101)
Affinity DataKi:  16nMAssay Description:Inhibition of human AChE assessed as inhibitor dissociation constant for enzyme-substrate-inhibitor complex pre-incubated for 6 mins before ATCI subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed