BDBM50457303 CHEMBL4207209

SMILES Cc1cc(F)c(CO)cc1Nc1nccc(n1)-c1cc2c(NC[C@]2(C)CO)c(c1)C#N

InChI Key InChIKey=ARQAEBRAXJPXEP-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50457303   

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Amri

Curated by ChEMBL

LigandBDBM50457303(CHEMBL4207209)Copy SMILESCopy InChI

Affinity DataIC50: 2.30nMAssay Description:Inhibition of recombinant human GST-tagged MAP3K14 autophosphorylation after 1 hr by Alpha screen assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Amri

Curated by ChEMBL

LigandBDBM50457303(CHEMBL4207209)Copy SMILESCopy InChI

Affinity DataIC50: 7.80nMAssay Description:Inhibition of MAP3K14 in human L363 assessed as decrease in IKKalpha phosphorylation level after 2 hrs by sandwich immuno assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL