BDBM50457306 CHEMBL4202865

SMILES CC(C)Oc1ccc(CO)cc1Nc1nccc(n1)-c1cc2c(NC[C@]2(C)CO)c(c1)C#N

InChI Key InChIKey=RISSKZZAQYAEKW-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50457306   

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Amri

Curated by ChEMBL

LigandBDBM50457306(CHEMBL4202865)Copy SMILESCopy InChI

Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant human GST-tagged MAP3K14 autophosphorylation after 1 hr by Alpha screen assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Amri

Curated by ChEMBL

LigandBDBM50457306(CHEMBL4202865)Copy SMILESCopy InChI

Affinity DataIC50: 6.60nMAssay Description:Inhibition of MAP3K14 in human L363 assessed as decrease in IKKalpha phosphorylation level after 2 hrs by sandwich immuno assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL