BDBM50457309 CHEMBL4212714

SMILES C[C@]1(CO)CNc2c1cc(cc2C#N)-c1ccnc(Nc2cc(ccc2OC2CC2)C#N)n1

InChI Key InChIKey=FUZOISPBFQGDJS-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50457309   

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Amri

Curated by ChEMBL

LigandBDBM50457309(CHEMBL4212714)Copy SMILESCopy InChI

Affinity DataIC50: 7.40nMAssay Description:Inhibition of recombinant human GST-tagged MAP3K14 autophosphorylation after 1 hr by Alpha screen assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Amri

Curated by ChEMBL

LigandBDBM50457309(CHEMBL4212714)Copy SMILESCopy InChI

Affinity DataIC50: 12nMAssay Description:Inhibition of MAP3K14 in human L363 assessed as decrease in IKKalpha phosphorylation level after 2 hrs by sandwich immuno assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL