BDBM50458161 CHEMBL246653

SMILES Fc1cccc(c1)C1CCCC(COC(=O)N2CCC(CC2)N2CCCCC2)N1S(=O)(=O)c1ccc(Cl)cc1

InChI Key InChIKey=SAJYZUZYZMJMOG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50458161   

TargetPresenilin-1(Human)
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50458161(CHEMBL246653)
Affinity DataIC50: 3nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as reduction in amyloid beta (1 to 42) productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50458161(CHEMBL246653)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cells by whole cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50458161(CHEMBL246653)
Affinity DataIC50: 11nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed