BDBM50458479 CHEMBL4212186

SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(Cc2ccc(s2)C(=O)NO)ccc1OCC

InChI Key InChIKey=NGFDENLSEDFSFN-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50458479   

TargetHistone deacetylase 6(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50458479(CHEMBL4212186)
Affinity DataIC50:  15nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 cells using fluorogenic HDAC substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50458479(CHEMBL4212186)
Affinity DataIC50:  841nMAssay Description:Inhibition of full length human recombinant C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected sf9 cells using fluorogenic HDAC subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50458479(CHEMBL4212186)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human HDAC9More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50458479(CHEMBL4212186)
Affinity DataIC50:  2.09E+3nMAssay Description:Inhibition of full length human recombinant C-terminal His-tagged HDAC3/N-terminal GST-tagged NCOR2 (95 to 489 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50458479(CHEMBL4212186)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of PDE6C (unknown origin) using FAM-cGMP as substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50458479(CHEMBL4212186)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50458479(CHEMBL4212186)
Affinity DataIC50:  11nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50458479(CHEMBL4212186)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of PDE3A (unknown origin) using FAM-cGMP as substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50458479(CHEMBL4212186)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human HDAC5More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50458479(CHEMBL4212186)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human HDAC4More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50458479(CHEMBL4212186)
Affinity DataIC50:  345nMAssay Description:Inhibition of full length human recombinant C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected sf9 cells using fluorogenic HDAC subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50458479(CHEMBL4212186)
Affinity DataIC50:  3.72E+3nMAssay Description:Inhibition of full length human recombinant C-terminal His-tagged HDAC2 expressed in baculovirus infected sf9 cells using fluorogenic HDAC substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50458479(CHEMBL4212186)
Affinity DataIC50:  11nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged PDE5A1 expressed in baculovirus infected sf9 cells using cGMP as substrate after 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50458479(CHEMBL4212186)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged PDE9A2 expressed in baculovirus infected sf9 cells using cGMP as substrate after 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed