BDBM50458479 CHEMBL4212186
SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(Cc2ccc(s2)C(=O)NO)ccc1OCC
InChI Key InChIKey=NGFDENLSEDFSFN-UHFFFAOYSA-N
Data 14 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50458479
Affinity DataIC50: 15nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 cells using fluorogenic HDAC substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 841nMAssay Description:Inhibition of full length human recombinant C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected sf9 cells using fluorogenic HDAC subst...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human HDAC9More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Navarra
Curated by ChEMBL
University of Navarra
Curated by ChEMBL
Affinity DataIC50: 2.09E+3nMAssay Description:Inhibition of full length human recombinant C-terminal His-tagged HDAC3/N-terminal GST-tagged NCOR2 (95 to 489 residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Human)
University of Navarra
Curated by ChEMBL
University of Navarra
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of PDE6C (unknown origin) using FAM-cGMP as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of PDE3A (unknown origin) using FAM-cGMP as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human HDAC5More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human HDAC4More data for this Ligand-Target Pair
Affinity DataIC50: 345nMAssay Description:Inhibition of full length human recombinant C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected sf9 cells using fluorogenic HDAC subst...More data for this Ligand-Target Pair
Affinity DataIC50: 3.72E+3nMAssay Description:Inhibition of full length human recombinant C-terminal His-tagged HDAC2 expressed in baculovirus infected sf9 cells using fluorogenic HDAC substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged PDE5A1 expressed in baculovirus infected sf9 cells using cGMP as substrate after 30...More data for this Ligand-Target Pair
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
University of Navarra
Curated by ChEMBL
University of Navarra
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged PDE9A2 expressed in baculovirus infected sf9 cells using cGMP as substrate after 30...More data for this Ligand-Target Pair