BDBM50458487 CHEMBL4214135

SMILES CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(Cc2ccc(s2)C(=O)NO)ccc1OCC

InChI Key InChIKey=UVAOACDYKCHCQN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50458487   

TargetHistone deacetylase 6(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50458487(CHEMBL4214135)
Affinity DataIC50:  98nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 cells using fluorogenic HDAC substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50458487(CHEMBL4214135)
Affinity DataIC50:  3nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged PDE5A1 expressed in baculovirus infected sf9 cells using cGMP as substrate after 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50458487(CHEMBL4214135)
Affinity DataIC50:  3nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50458487(CHEMBL4214135)
Affinity DataIC50:  793nMAssay Description:Inhibition of full length human recombinant C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected sf9 cells using fluorogenic HDAC subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50458487(CHEMBL4214135)
Affinity DataIC50:  4.39E+3nMAssay Description:Inhibition of full length human recombinant C-terminal His-tagged HDAC2 expressed in baculovirus infected sf9 cells using fluorogenic HDAC substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed