BDBM50458603 CHEMBL4216529::US10752615, Compound 42

SMILES O[C@H]1CC[C@@H](CC1)NCc1ccc2n([C@H]3C[C@]4(C3)CCN(C4)C(=O)C=C)c(NC(=O)c3ccc(s3)-c3cnco3)nc2c1

InChI Key InChIKey=UNSFWPUQRXYWKE-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50458603   

TargetTyrosine-protein kinase TXK(Human)
Gb005

US Patent
LigandPNGBDBM50458603(CHEMBL4216529 | US10752615, Compound 42)
Affinity DataIC50: 0.320nMAssay Description:The in vitro kinase assays were performed at Nanosyn (Santa Clara, Calif.) utilizing microfluidic detection technology. The test compounds were seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetTyrosine-protein kinase TXK(Human)
Gb005

US Patent
LigandPNGBDBM50458603(CHEMBL4216529 | US10752615, Compound 42)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of TXK (unknown origin) using fluorescently labeled peptide as substrate after 3 hrs by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Gb005

US Patent
LigandPNGBDBM50458603(CHEMBL4216529 | US10752615, Compound 42)
Affinity DataIC50: 0.530nMAssay Description:The in vitro kinase assays were performed at Nanosyn (Santa Clara, Calif.) utilizing microfluidic detection technology. The test compounds were seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Gb005

US Patent
LigandPNGBDBM50458603(CHEMBL4216529 | US10752615, Compound 42)
Affinity DataIC50: 0.530nMAssay Description:Inhibition of BTK (unknown origin) using fluorescently labeled peptide as substrate after 3 hrs by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50458603(CHEMBL4216529 | US10752615, Compound 42)
Affinity DataIC50: 0.640nMAssay Description:Inhibition of ITK (unknown origin) using fluorescently labeled peptide as substrate after 3 hrs by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50458603(CHEMBL4216529 | US10752615, Compound 42)
Affinity DataIC50: 0.640nMAssay Description:The in vitro kinase assays were performed at Nanosyn (Santa Clara, Calif.) utilizing microfluidic detection technology. The test compounds were seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Tec(Human)
Gb005

US Patent
LigandPNGBDBM50458603(CHEMBL4216529 | US10752615, Compound 42)
Affinity DataIC50: 2nMAssay Description:The in vitro kinase assays were performed at Nanosyn (Santa Clara, Calif.) utilizing microfluidic detection technology. The test compounds were seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Tec(Human)
Gb005

US Patent
LigandPNGBDBM50458603(CHEMBL4216529 | US10752615, Compound 42)
Affinity DataIC50: 2nMAssay Description:Inhibition of TEC (unknown origin) using fluorescently labeled peptide as substrate after 3 hrs by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed