BDBM50458630 CHEMBL4203429

SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CS(C)(=O)=O)c(c2)C(F)(F)F)c(F)c1

InChI Key InChIKey=BEXCPFCIYIOGDW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50458630   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50458630(CHEMBL4203429)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human RET using cisbio TK biotin-peptide as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr by HT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50458630(CHEMBL4203429)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of RET phosphorylation in human TT cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50458630(CHEMBL4203429)
Affinity DataIC50: 21nMAssay Description:Inhibition of human KDR using cisbio TK biotin-peptide as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed