BDBM50459146 CHEMBL4202656

SMILES Cn1c(SCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc34)cc2Cl)ncc1C(O)=O

InChI Key InChIKey=GTUHEHCURMGSCI-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50459146   

TargetG-protein coupled bile acid receptor 1(Mouse)
Ardelyx

Curated by ChEMBL
LigandPNGBDBM50459146(CHEMBL4202656)
Affinity DataEC50:  10nMAssay Description:Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Ardelyx

Curated by ChEMBL
LigandPNGBDBM50459146(CHEMBL4202656)
Affinity DataEC50:  316nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed