BDBM50459163 CHEMBL4210889

SMILES Oc1ccc(Cc2[nH]c(-c3cccs3)c3c2oc2ccccc2c3=O)cc1

InChI Key InChIKey=GPIHPADNHDARBD-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50459163   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50459163(CHEMBL4210889)
Affinity DataIC50:  17nMAssay Description:Inhibition of human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 mins by liqu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50459163(CHEMBL4210889)
Affinity DataIC50:  17nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50459163(CHEMBL4210889)
Affinity DataIC50:  17nMAssay Description:Antagonistic affinity tested against isolated Rat Prostatic Vas Deferens Alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50459163(CHEMBL4210889)
Affinity DataIC50:  17nMAssay Description:Inhibition of recombinant human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cGMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50459163(CHEMBL4210889)
Affinity DataIC50:  17nMAssay Description:Inhibition of recombinant human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cGMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB