BDBM50459693 CHEMBL4215953::US12006283, Example 8

SMILES COc1ccc(cc1OC)C(C)C(=O)c1ccc(cc1OC)N1CCOCC1

InChI Key InChIKey=IRMAECQTQCVIII-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50459693   

TargetHypoxia-inducible factor 1-alpha(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50459693(CHEMBL4215953 | US12006283, Example 8)
Affinity DataIC50: 8.74E+3nMAssay Description:Inhibition of HIF-1alpha in human HRE-A549 cells pre-incubated for 1 hr before exposure to hypoxia for 24 hrs by HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHypoxia-inducible factor 1-alpha(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50459693(CHEMBL4215953 | US12006283, Example 8)
Affinity DataIC50: 8.74E+3nMAssay Description:The experiment was performed in order to evaluate inhibitory activity against angiogenesis of the compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
US Patent