BDBM50460773 CHEMBL4227082
SMILES Cc1cn2c(cnc2c(Nc2cc(Cc3ccccn3)ns2)n1)-c1cn[nH]c1
InChI Key InChIKey=NNQHKTWARZSGTQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 31 hits for monomerid = 50460773
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Merck
Curated by ChEMBL
Merck
Curated by ChEMBL
Affinity DataIC50: >500nMAssay Description:Inhibition of IKKB (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >500nMAssay Description:Inhibition of GSK3b (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >500nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: <4nMAssay Description:Inhibition of Aurora A (unknown origin) using Tamra-PKAtide as substrate by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.0100nMAssay Description:Binding affinity to Aurora A (unknown origin) after 45 mins by fluorescence-based thermal stability shift assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.100nMAssay Description:Binding affinity to Aurora B (unknown origin) after 45 mins by fluorescence-based thermal stability shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 271nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >500nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type IV(Homo sapiens (Human))
Merck
Curated by ChEMBL
Merck
Curated by ChEMBL
Affinity DataIC50: >500nMAssay Description:Inhibition of CAMK4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >500nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >500nMAssay Description:Inhibition of CSNK1D (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >500nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >500nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >500nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >500nMAssay Description:Inhibition of MST2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >500nMAssay Description:Inhibition of PKCA (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >500nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >500nMAssay Description:Inhibition of TSSK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 390nMAssay Description:Inhibition of EPHB4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >500nMAssay Description:Inhibition of NEK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >500nMAssay Description:Inhibition of PLK3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: >20nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataEC50: 117nMAssay Description:Inhibition of Aurora B in human HCT116 cells assessed as reduction in phosphorylation of Histone H3 at Ser10 residue incubated for 1 hr by Hoechst 33...More data for this Ligand-Target Pair
Affinity DataIC50: <13nMAssay Description:Inhibition of Aurora B (unknown origin) using Tamra-PKAtide as substrate by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of RSK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >500nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair