BDBM50460858 CHEMBL4225528::US11116757, No. A294

SMILES CCOc1cc(CN2CCC(CC2)N(Cc2ccccc2)C(=O)Nc2cccc(c2)C(F)(F)F)cc(Cl)c1O

InChI Key InChIKey=OPSPOAAGWPFMIP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50460858   

TargetDCN1-like protein 1(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50460858BDBM50460858(CHEMBL4225528 | US11116757, No. A294)
Affinity DataIC50: 6.70E+4nMAssay Description:Binding affinity biotinylated human GST-tagged DCN1 assessed as inhibition of protein interaction with AlexaFluor 488-tagged and N-terminally acetyla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetDCN1-like protein 1/NEDD8-conjugating enzyme Ubc12(Human)
Memorial Sloan Kettering Cancer Center

US Patent
LigandChemical structure of BindingDB Monomer ID 50460858BDBM50460858(CHEMBL4225528 | US11116757, No. A294)
Affinity DataIC50: 8.10E+4nMAssay Description:The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
US Patent