BDBM50465064 CHEMBL4294322::US10550080, Example 36

SMILES CCS(=O)(=O)NC(=O)c1ccc2c(cn(C)c2c1)-c1cnc(OCC(C)C)c(Cl)c1

InChI Key InChIKey=PMZAJXSRPAMGQD-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50465064   

TargetSodium channel protein type 5 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465064(CHEMBL4294322 | US10550080, Example 36)
Affinity DataIC50:  5.67E+3nMAssay Description:Inhibition of Nav1.5 (unknown origin) expressed in HEK293 cells at -40 mV holding potential measured after 600 secs by patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465064(CHEMBL4294322 | US10550080, Example 36)
Affinity DataIC50:  154nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells at -60 mV holding potential measured after 600 secs by patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465064(CHEMBL4294322 | US10550080, Example 36)
Affinity DataIC50:  38nMAssay Description:Displacement of [3H]-labelled radioligand from human Nav1.7 expressed in HEK293 cells measured after 24 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465064(CHEMBL4294322 | US10550080, Example 36)
Affinity DataIC50:  154nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells after 600 secs at -60 mV holding potential by ion works barracuda population patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465064(CHEMBL4294322 | US10550080, Example 36)
Affinity DataIC50:  38nMAssay Description:hNaV1.7 binding affinities were determined with a filtration binding assay using purified membranes from HEK293 cells stably expressing hNaV1.7. HEK2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465064(CHEMBL4294322 | US10550080, Example 36)
Affinity DataIC50:  5.67E+3nMAssay Description:Ion Works Barracuda population patch clamp (PPC). PPC measurements were performed using an IonWorks Barracuda instrument (Molecular Devices Corporati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465064(CHEMBL4294322 | US10550080, Example 36)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells after 600 secs at -50 mV holding potential by ion works barracuda population patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465064(CHEMBL4294322 | US10550080, Example 36)
Affinity DataIC50:  154nMAssay Description:Ion Works Barracuda population patch clamp (PPC). PPC measurements were performed using an IonWorks Barracuda instrument (Molecular Devices Corporati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent