BDBM50466136 CHEMBL4292463::US11547712, Compound 3-12

SMILES Clc1ccc(CNC2=NN=C(CS2)c2ccc3[nH]c(=O)[nH]c3c2)cc1

InChI Key InChIKey=SDWZEMHPBPRVPC-UHFFFAOYSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50466136   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Icahn School of Medicine At Mount Sinai

US Patent
LigandPNGBDBM50466136(CHEMBL4292463 | US11547712, Compound 3-12)
Affinity DataKd:  185nMAssay Description:Compound 1, a 1,3,4-thiadiazine compound identified in a screening assay, was evaluated for testing of in vitro DYRK1A activity at 30 μM concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Icahn School of Medicine At Mount Sinai

US Patent
LigandPNGBDBM50466136(CHEMBL4292463 | US11547712, Compound 3-12)
Affinity DataKd:  185nMAssay Description:Binding affinity to DYRK1A (unknown origin) assessed as dissociation constant at 3 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Icahn School of Medicine At Mount Sinai

US Patent
LigandPNGBDBM50466136(CHEMBL4292463 | US11547712, Compound 3-12)
Affinity DataKd:  185nMAssay Description:Binding affinity to wild-type human partial length DYRK1A (H129 to S509 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed