BDBM50466142 CHEMBL4280876::US11547712, Compound 3-25

SMILES CC(NC1=NN=C(CS1)c1ccc2[nH]c(=O)[nH]c2c1)c1ccccc1

InChI Key InChIKey=ARZSEJWAYZPZPI-UHFFFAOYSA-N

Data  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50466142   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Icahn School of Medicine At Mount Sinai

US Patent
LigandPNGBDBM50466142(CHEMBL4280876 | US11547712, Compound 3-25)
Affinity DataKd:  1.10E+3nMAssay Description:Compound 1, a 1,3,4-thiadiazine compound identified in a screening assay, was evaluated for testing of in vitro DYRK1A activity at 30 μM concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Icahn School of Medicine At Mount Sinai

US Patent
LigandPNGBDBM50466142(CHEMBL4280876 | US11547712, Compound 3-25)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to wild-type human partial length DYRK1A (H129 to S509 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed