BDBM50466900 CHEMBL4277076

SMILES Cn1cc(C2CCN(CC2)C(=O)C2CCCC2)c2cc(NC(=O)c3ccccc3)ccc12

InChI Key InChIKey=HDODSTJVQWRICU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50466900   

TargetNuclear receptor ROR-gamma(Human)
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466900(CHEMBL4277076)
Affinity DataIC50: 56nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466900(CHEMBL4277076)
Affinity DataIC50: 880nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNuclear receptor ROR-alpha(Human)
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466900(CHEMBL4277076)
Affinity DataIC50: 3.00E+4nMAssay Description:Inverse agonist activity at RORA (unknown origin) assessed as inhibition of biotinylated co-activator SRC1-2 peptide recruitment after 3 hrs by TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNuclear receptor ROR-beta(Human)
Karo Pharma

Curated by ChEMBL
LigandPNGBDBM50466900(CHEMBL4277076)
Affinity DataIC50: 3.00E+4nMAssay Description:Inverse agonist activity at RORB (unknown origin) assessed as inhibition of biotinylated co-activator SRC1-2 peptide recruitment after 3 hrs by TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed