BDBM50467474 CHEMBL4289471

SMILES [H][C@]12Cc3c([nH]c4ccccc34)[C@H](N1C(=O)CN(C)C2=O)c1ccc(Br)s1

InChI Key InChIKey=KUYGOKWGSHFXJD-FZKQIMNGSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50467474   

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467474(CHEMBL4289471)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PDE3B (592 to end residues) expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Rat)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467474(CHEMBL4289471)
Affinity DataEC50:  55nMAssay Description:Inhibition of PDE5 in Wistar rat mesentric arteries assessed as inhibition of phenylephrine-induced contraction by measuring increase in acetylcholin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467474(CHEMBL4289471)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PDE2A (2 to 941 residues) expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50467474(CHEMBL4289471)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE1A expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50467474(CHEMBL4289471)
Affinity DataIC50:  136nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467474(CHEMBL4289471)
Affinity DataIC50:  219nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE11A4 expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467474(CHEMBL4289471)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE5A1 expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-GMP as sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50467474(CHEMBL4289471)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE4A1A expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed