BDBM50468116 CHEMBL4276697::US11247985, Table 3.91

SMILES CC(C)N1CCN(C(=O)CCNC2CCN(c3cccc(-c4cc5cc(F)ccc5[nH]4)c3)CC2)CC1

InChI Key InChIKey=ONNZBWRDFXPSNM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50468116   

TargetSmall VCP/p97-interacting protein(Human)
University Of Pittsburgh

US Patent
LigandChemical structure of BindingDB Monomer ID 50468116BDBM50468116(CHEMBL4276697 | US11247985, Table 3.91 | US1255948...)
Affinity DataIC50: 120nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2026
Entry Details US Patent

TargetTransitional endoplasmic reticulum ATPase(Human)
University of Pittsburgh

US Patent
LigandChemical structure of BindingDB Monomer ID 50468116BDBM50468116(CHEMBL4276697 | US11247985, Table 3.91 | US1255948...)
Affinity DataIC50: 120nMAssay Description:To optimize p97 inhibitors, the C-5 trifluoromethylated trifluoromethylated indole 12 was generated as a promising lead structure. In the ADP-Glo ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetTransitional endoplasmic reticulum ATPase(Human)
University of Pittsburgh

US Patent
LigandChemical structure of BindingDB Monomer ID 50468116BDBM50468116(CHEMBL4276697 | US11247985, Table 3.91 | US1255948...)
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant full length human p97 (1 to 806 residues) expressed in Escherichia coli Rosetta 2 (DE3) using 100 uM ATP as substrate after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed