BDBM50468122 CHEMBL4291849::US11247985, Table 3.15

SMILES CCN1CCN(CCNC2CCN(c3cccc(-c4cc5ccccc5[nH]4)c3)CC2)CC1

InChI Key InChIKey=NQQOVGJHJIABGB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50468122   

TargetSmall VCP/p97-interacting protein(Human)
University Of Pittsburgh

US Patent
LigandChemical structure of BindingDB Monomer ID 50468122BDBM50468122(CHEMBL4291849 | US11247985, Table 3.15 | US1255948...)
Affinity DataIC50: 190nMAssay Description:HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2026
Entry Details US Patent

TargetTransitional endoplasmic reticulum ATPase(Human)
University of Pittsburgh

US Patent
LigandChemical structure of BindingDB Monomer ID 50468122BDBM50468122(CHEMBL4291849 | US11247985, Table 3.15 | US1255948...)
Affinity DataIC50: 190nMAssay Description:To optimize p97 inhibitors, the C-5 trifluoromethylated trifluoromethylated indole 12 was generated as a promising lead structure. In the ADP-Glo ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetTransitional endoplasmic reticulum ATPase(Human)
University of Pittsburgh

US Patent
LigandChemical structure of BindingDB Monomer ID 50468122BDBM50468122(CHEMBL4291849 | US11247985, Table 3.15 | US1255948...)
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant full length human p97 (1 to 806 residues) expressed in Escherichia coli Rosetta 2 (DE3) using 100 uM ATP as substrate after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed