BDBM50468978 CHEMBL4291778

SMILES CC(C)(C)OC(=O)N1CCC2(CN(Cc3ccc(cc3)C(=O)NO)c3ccccc23)CC1

InChI Key InChIKey=FNIIPERYFWUVCR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50468978   

TargetHistone deacetylase 6(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50468978(CHEMBL4291778)
Affinity DataIC50: 42nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged full length HDAC6 expressed in insect SF9 cells using fluorogenic ZMAL as substrate after 90 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50468978(CHEMBL4291778)
Affinity DataIC50: 42nMAssay Description:Inhibition of full length N-terminal GST-tagged human HDAC6 expressed in baculovirus expression system using ZMAL as substrate incubated for 90 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50468978(CHEMBL4291778)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human recombinant HDAC8 using fluor de Lys(R) as substrate after 90 mins by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50468978(CHEMBL4291778)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant C-terminal His/FLAG-tagged full length HDAC1 expressed in insect SF9 cells using fluorogenic ZMAL as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50468978(CHEMBL4291778)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human HDAC1 expressed in baculovirus expression system using ZMAL as substrate incubated for 90 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed