BDBM50474685 CHEMBL356824

SMILES ONC(=O)c1ccc(NC(=O)Cc2ccccc2)cc1

InChI Key InChIKey=VQGKLYBEQDAOSV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50474685   

TargetHistone deacetylase 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50474685(CHEMBL356824)
Affinity DataIC50: 75nMAssay Description:Inhibition of human recombinant HDAC1 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50474685(CHEMBL356824)
Affinity DataIC50: 110nMAssay Description:Inhibition of histone deacetylase (HDAC) activity in DU-145 nuclear extractsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50474685(CHEMBL356824)
Affinity DataIC50: 157nMAssay Description:In vitro inhibitory concentration against histone deacetylase of DU-145 prostate cell nuclear extract as deacetylation of biotinylated [3H]-acetyl hi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed