BDBM50477644 CHEMBL248605

SMILES CC(C(=O)OCc1ccccc1)c1ccc2c(c1)n(c1ccc(Cl)cc21)S(=O)(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=VHXQZGKRDQETRR-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50477644   

TargetPresenilin-1(Human)
Darmstadt University of Technology

Curated by ChEMBL
LigandPNGBDBM50477644(CHEMBL248605)
Affinity DataEC50: >2.00E+4nMAssay Description:Effect on gamma-secretase activity in human H4 cells expressing APP695 assessed as increase in Amyloid beta-42 formation LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Darmstadt University of Technology

Curated by ChEMBL
LigandPNGBDBM50477644(CHEMBL248605)
Affinity DataIC50: 2.00E+4nMAssay Description:Effect on gamma-secretase activity in human H4 cells expressing APP695 assessed as reduction of Amyloid beta-38 formation by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Darmstadt University of Technology

Curated by ChEMBL
LigandPNGBDBM50477644(CHEMBL248605)
Affinity DataIC50: 4.00E+4nMAssay Description:Effect on gamma-secretase activity in human H4 cells expressing APP695 assessed as reduction of Amyloid beta-40 formation LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed