BDBM50477645 CHEMBL249202

SMILES CCCCCCCCN(c1ccc(OCC(O)=O)cc1)S(=O)(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=CBMGDIGTWVHVOC-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50477645   

TargetPresenilin-1(Human)
Darmstadt University of Technology

Curated by ChEMBL
LigandPNGBDBM50477645(CHEMBL249202)
Affinity DataIC50: 1.96E+4nMAssay Description:Effect on gamma-secretase activity in human H4 cells expressing APP695 assessed as reduction of Amyloid beta-42 formation LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Darmstadt University of Technology

Curated by ChEMBL
LigandPNGBDBM50477645(CHEMBL249202)
Affinity DataEC50:  2.37E+4nMAssay Description:Effect on gamma-secretase activity in human H4 cells expressing APP695 assessed as increase in Amyloid beta38 formation by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Darmstadt University of Technology

Curated by ChEMBL
LigandPNGBDBM50477645(CHEMBL249202)
Affinity DataIC50: 4.00E+4nMAssay Description:Effect on gamma-secretase activity in human H4 cells expressing APP695 assessed as reduction of Amyloid beta-40 formation LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed