BDBM50479452 CHEMBL461556

SMILES CC[C@H](CO)Nc1nc(NCc2ccc(cc2)-c2ccncc2)c2ncn(C(C)C)c2n1

InChI Key InChIKey=UQRBOMYWGJFNEB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50479452   

TargetCyclin-dependent kinase 12(Human)
UCB

Curated by ChEMBL
LigandPNGBDBM50479452(CHEMBL461556)
Affinity DataEC50:  36nMAssay Description:Inhibition of 6His-tagged wild type CDK12/cyclin K (unknown origin) infected in insect cells incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta/[Tau protein] kinase(Pig)
Universite Paris-Descartes

Curated by ChEMBL
LigandPNGBDBM50479452(CHEMBL461556)
Affinity DataIC50: 3.55E+4nMAssay Description:Inhibition of pig brain GSK3alpha/betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed