BDBM50480115 CHEMBL496019

SMILES COc1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)ccc1Oc1ccnc2[nH]c(=O)[nH]c12

InChI Key InChIKey=VQBCAPWCMULUPW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50480115   

TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50480115(CHEMBL496019)
Affinity DataIC50: 25nMAssay Description:Inhibition of BRAF V600E mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50480115(CHEMBL496019)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed