BDBM50483255 CHEMBL1643425

SMILES COc1cc(ccc1-n1cnc(C)c1)-c1nnc2N(CCCn12)C(C)c1cc(F)c(F)c(F)c1

InChI Key InChIKey=VZKJTPSJNUXRPA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50483255   

TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50483255(CHEMBL1643425)
Affinity DataIC50: 116nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells by sandwich immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50483255(CHEMBL1643425)
Affinity DataIC50: 116nMAssay Description:Modulation of gamma secretase in HEK293 cells transfected with human APP with Swedish and London familial AD mutation assessed as reduction in Abeta4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed