BDBM50483927 CHEMBL3183531

SMILES CCOC(=O)CCNc1cc(nc(n1)-c1ccccn1)N1CCc2ccccc2CC1

InChI Key InChIKey=WBKCKEHGXNWYMO-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50483927   

LigandPNGBDBM50483927(CHEMBL3183531)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of KDM5C (2 to 1560 residues)(unknown origin) by Alphalisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50483927(CHEMBL3183531)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of KDM2B (1 to 650 residues)(unknown origin) by Alphalisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50483927(CHEMBL3183531)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of epitope-tagged KDM6B (1026 to 1682 residues)(unknown origin) transfected in human U2OS cells using H3K27me2 peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50483927(CHEMBL3183531)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of KDM4B (2 to 500 residues)(unknown origin) by Alphalisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50483927(CHEMBL3183531)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of PHF8 (1 to 1024 residues)(unknown origin) by Alphalisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50483927(CHEMBL3183531)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of KDM4C (1 to 349 residues)(unknown origin) by Alphalisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50483927(CHEMBL3183531)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of KDM6A (919 to 1401 residues)(unknown origin) by Alphalisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50483927(CHEMBL3183531)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of KDM3B (842 to 1761 residues)(unknown origin) by Alphalisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50483927(CHEMBL3183531)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of epitope-tagged full length KDM4C (unknown origin) transfected in human U2OS cells using H3K9me3 peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50483927(CHEMBL3183531)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of KDM4A (1 to 350 residues)(unknown origin) by Alphalisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50483927(CHEMBL3183531)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of KDM3A (2 to 1322 residues)(unknown origin) by Alphalisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50483927(CHEMBL3183531)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of KDM6B (1043 to 1643 residues)(unknown origin) by Alphalisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50483927(CHEMBL3183531)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of KDM5B (1 to 809 residues)(unknown origin) by Alphalisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50483927(CHEMBL3183531)
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of JMJD3 (unknown origin) by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM50483927(CHEMBL3183531)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50483927(CHEMBL3183531)
Affinity DataEC50:  1.60E+4nMAssay Description:Inhibition of tetracyclin/Dox-inducible N-terminal 3xFLAG/C-terminal GFP tagged human TET1 catalytic domain (1481 to 2136 residues) expressed in huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
LigandPNGBDBM50483927(CHEMBL3183531)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of KDM6B (unknown origin) by mass spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50483927(CHEMBL3183531)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human N-terminal His6/Flag-tagged TEV-protease cleavage site fused JMJD3 1637-1675 deletion mutant (1141 to 1682 residues) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed